2016 Global Health & Infectious Disease: Cancer: Novel Targets and Therapies

Despite billions of dollars, decades of research, and an unparalleled level of international cooperation between research scientists and clinicians, cancer remains a major cause of death worldwide. Therapies have improved and many forms of cancer are now treatable, but the disease still kills over eight million people throughout the world each year. For this reason, cancer research funding represents one of the largest expenditures of the United States federal government, and has led to improved medical treatments as well as greater understanding of the molecular intricacies of the disease. However, because cancer is now considered not simply one disease, but rather a multitude of independent disorders that can all result in malignant cellular growth, the dream of a cure for cancer, the “magic bullet”, to miraculously eliminate the disease, is now considered unrealistic in light of these overwhelming complexities. The interdisciplinary approach that has emerged is offering new hope for therapies and treatment. Since not all tumors are the same, molecular targeting, or the attempt to tailor therapy to the specific abnormalities causing disease, has become one of the most promising areas in cancer biology research. By combining molecular biology and biochemistry with combinatorial chemistry and organic chemistry, pharmaceutical research has embraced the field of rational drug design as a specific application of molecular targeting. In the past few years, the rapidly advancing field of cancer immunology has produced several new methods of treating cancer. These immunotherapies increase the strength of immune responses against tumors. However, cancer cells are sometimes able to avoid detection and destruction by the immune system. Drug development takes time, and it is years, often decades, before a drug that shows promise in the lab will make it into the clinic. And of course, resistance to chemotherapy and molecularly targeted therapies remains a major problem. This symposium seeks to highlight some of the innovative and creative approaches being pursued in light of these challenges.

About the Brother Lucian Blersch Symposium

Organized by the School of Natural Sciences at St. Edward’s University, the event is free and open to the public. This symposium honors Brother Lucian Blersch, CSC, a longtime professor of Engineering at St. Edward’s who died in 1986 and in whose name a professorship in the School of Natural Sciences was endowed by a gift from J.B.N. Morris hs ’48, ’52, and his family.

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